Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

Completed

• Conditions: Sepsis

• Registration Number: NCT00410111
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown. We will investigate whether patients who develop this condition have different patterns of cerebrovascular reactivity and whether it is possible to predict the development of septic encephalopathy from early measurements of cerebral perfusion or from the EEG. We will specifically test the hypotheses that septic encephalopathy may not be predicted by changes in the EEG, and that cerebrovascular autoregulation is not dysfunctional in septic encephalopathy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2006-12-11
• Study First Submitted QC: 2006-12-11
• Study First Posted: 2006-12-12
• Study Start: 2007-01
• Study Completion: 2007-07
• Status Verified: 2008-10
• Last Update Submitted: 2008-10-15
• Last Update Posted: 2008-10-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 23

Inclusion Criteria

• Sepsis
• Admission to ICU

Exclusion Criteria

• CNS infection
• History of cerebrovascular disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Operative Intensivbehandlung, University of Basel Hospital; 🇨🇭 Basel, Switzerland