Esophageal Manometry in Mechanically Ventilated Patients
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Sahlgrenska University Hospital, Sweden
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Esophageal pressure measurements in mechanically ventilated patients
Overview
Brief Summary
Esophageal pressure measurements are used in to determine chest wall elastance and calculate lung elastance and transpulmonary pressure in mechanically ventilated patients. A dedicated esophageal balloon catheter is then placed in the esophagus to measure tidal variations in esophageal pressure.
In this study high resolution solid-state manometry technique was used to provide detailed and continuous measurements of esophageal pressures in the different parts of the esophagus. Measurements were performed during ongoing mechanical ventilation at different levels of endexpiratory pressure.
Detailed Description
Esophageal pressure measurements are used in to determine chest wall elastance and calculate lung elastance and transpulmonary pressure in mechanically ventilated patients. A dedicated esophageal balloon catheter is then placed in the esophagus to measure tidal variations in esophageal pressure.
In this study high resolution solid-state manometry technique was instead used to provide detailed and continuous measurements of esophageal pressures in the different parts of the esophagus. The manometry catheter has 36 circumferential sensors at 1 cm intervals. Each sensor has 12 pressure-sensitive segments that add to the signal at that location. Measurements were performed during ongoing mechanical ventilation at different levels of endexpiratory pressure. Possible differences in tidal variations in esophageal pressure in different parts of the esophagus were assessed.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients in the critical care unit receiving mechanical ventilation or Patients anesthetized and undergoing surgery
Exclusion Criteria
- •Patients with a contraindication to insert a catheter in the esophagus for instance due to an operation.
Outcomes
Primary Outcomes
Esophageal pressure measurements in mechanically ventilated patients
Time Frame: Within one hour
Esophageal pressure was measured in mechanically ventilated patients in the critical care unit and in the operating room.
Secondary Outcomes
No secondary outcomes reported
Investigators
Stefan Lundin
Professor
Sahlgrenska University Hospital, Sweden