Respiratory Care in Intensive Care Unit for Neuromuscular Patients

• Conditions: Respiratory Failure
• Interventions: Other: Ventilatory support

• Registration Number: NCT02936908
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Retrospective multicentric observational study exploring the population of adult neuromuscular patients presenting a respiratory distress requiring their admission in an Intensive Care Unit (ICU) for ventilatory support.

Research of markers associated with long term mortality and ventilatory status.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-08
• Study First Submitted: 2016-08-19
• Study First Submitted QC: 2016-10-14
• Study First Posted: 2016-10-18
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-28
• Last Update Posted: 2017-08-29
• Primary Completion: 2017-10
• Study Completion: 2017-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Patient > 18 years old
• First stay in a ICU ward
• Inclusion period : Admission in ICU between 01/01/2007 and 31/12/2015
• Presenting an acute respiratory distress at admission or during ICU stay
• Diagnosis of neuromuscular disease confirmed before Hospital discharge

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Exclusion Criteria

• Absence of respiratory failure during ICU stay (ICU stay for monitoring or for a specialized invasive procedure in the absence of respiratory failure, for example)
• Neuromuscular disease not proven or uncertain diagnosis
• Anterior admission in ICU ward for vital organ failure

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Ventilatory support	Ventilatory support	Adult patients presenting a neuromuscular disease, with involvement of respiratory or bulbar muscles

Primary Outcome Measures

Name	Time	Method
Mortality	until 2016.12.31	number of death

Secondary Outcome Measures

Name	Time	Method
Definitive long term invasive ventilatory support	until 2016.12.31	Date of tracheotomy for definitive long term invasive ventilatory support
Mortality attributable to a respiratory issue	until 2016.12.31	For patients for which this information is available, cause of death described as reliable to a respiratory issue in any medical document available.
Re-hospitalization in a ICU-Ward	until 2016.12.31	clinical deterioration requiring a new hospitalization in a ICU ward, after first hospitalization discharge.

Trial Locations

Locations (4)

Hôpital de la Croix Rousse; 🇫🇷 Lyon, France

CHU Clermont Ferrand; 🇫🇷 Clermont Ferrand, France

CHU Grenoble; 🇫🇷 Grenoble, France

Hôpital Nord CHU St Etienne; 🇫🇷 St Etienne, France