Minocycline as a new treatment for depressio

Phase 2

Completed

• Conditions: nipolar depression; Unipolar depression; Mental Health - Depression

• Registration Number: ACTRN12612000283875
• Lead Sponsor: Mental Health Research Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-03-09
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Aged 18 or over
-Capacity to consent to the study and to follow its instructions and procedures
-Fulfil the DSM-IV-TR diagnostic criteria for major depressive disorder, single episode or recurrent, as well as scoring 20 or over on the MADRS, at the baseline visit
-Participants on antidepressant therapy need to have been on the same treatment for at least two weeks prior to randomisation
-Utilising effective contraception (other than the contraceptive pill due to drug interactions) if female of child-bearing age and sexually active

Exclusion Criteria

-Concurrent diagnosis of bipolar disorder I, II or NOS -Three or more failed adequate trials of antidepressant therapy for the current major depressive episode or ECT for the current major depressive episode -Known or suspected clinically unstable systemic medical disorder (including a pre-existing infectious illness requiring tetracycline antibiotic treatment) -Pregnancy or breastfeeding -Contraindications to tetracyclines, including allergy or other intolerance; prior tetracycline use within 2 months of baseline visit -Current treatment with >5 mg beta caretone or >300 micrograms retinol equivalent. -Current treatment with anticoagulants; -Current treatment with methoxyflurane -Current treatment with penicillin -Females of childbearing age currently relying solely on the contraceptive pill as contraception.

Study & Design

• Study Type: Interventional
• Study Design: Not specified