Study of efficacy and safety of minocycline in pleurodesis
Phase 2
Recruiting
- Conditions
- Postoperative pulmonary fistulaair leakage
- Registration Number
- JPRN-jRCTs061210024
- Lead Sponsor
- Toyooka Shinichi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 19
Inclusion Criteria
1) Cases with postoperative pulmonary fistula at the postoperative day 3
2) The drainage from the chest tube are not bloody, purulent or chylous, and the volume of the drainage for 24 hours is 300 mL or less
3) Age of 20 years or older
4) Signed informed consent
Exclusion Criteria
1) Allergy against minocycline
2) Other patients who are unfit for the study as determined by the attending physician
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Frequency of removal of the chest tube after the protocol treatment (intrapleural administration of minocycline, up to twice)<br>If the recurrence of pulmonary fistula is observed within 1 week after the removal of the chest tube, such cases are omitted
- Secondary Outcome Measures
Name Time Method 1) Frequency of adverse events<br>2) Time period until the recurrence of pulmonary fistula