Efficacy of add on oral minocycline in children with acute encephalitis syndrome aged 1 month-18 years
- Conditions
- Health Condition 1: G049- Encephalitis, myelitis and encephalomyelitis, unspecified
- Registration Number
- CTRI/2024/07/070172
- Lead Sponsor
- All India Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1.Children between age 1 month-18 years of age
2. Presenting to department of pediatrics, AIIMS Rishikesh with a clinical diagnosis of acute encephalitis syndrome
3. Parents willing to comply with the study protocol and follow up
1.Preexisting major chronic systemic illness including cardiovascular, respiratory, gastrointestinal system or chronic renal disease
2.Preexisting developmental delay or intellectual disability
3.Definite diagnosis of neurometabolic or neurodegenerative disease
4.Caregivers not giving informed consent
5.History of allergy to minocycline previously
6.Children in whom Minocycline can’t be administered orally or through nasogastric tube within 72 hours of presenting to our institute due to clinical contraindications
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome is change in FSS scale score at 12 weeks as compared to baseline.Timepoint: baseline and 12 weeks
- Secondary Outcome Measures
Name Time Method change in Glassgow coma scaleTimepoint: day0, day7 and 12 weeks;Change in Paediatric cerebral performance category scoreTimepoint: baseline day 7 and day 12;Childhood Behavioural ChecklistTimepoint: 12 weeks <br/ ><br>;duration of hospitalisationTimepoint: 12 weeks <br/ ><br>;mortalityTimepoint: day 7 and 12 weeks <br/ ><br>;PedsQL scoreTimepoint: 12 weeks;Vineland adaptive behavior scoreTimepoint: 12 weeks <br/ ><br>;Vineland social maturity scoreTimepoint: 12 weeks