ong-term efficacy and adverse events of minocycline on neurological recovery in patients with acute stroke: A randomized, double-blind, placebo-controlled trial protocol
- Registration Number
- TCTR20220419008
- Lead Sponsor
- Min Zhao
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 71
1.Patients diagnosed with acute stroke . 2.Over 18 years of age.3.Patients with stable vital signs.4.Voluntarily participate in this study and sign the informed consent.5.Have certain expression, understanding and communication ability.6.Complete clinical data.
Exclusion criteria (Criteria used to identify patients unable to participate in the trial): 1.Patients with malignant tumor, immune or hematopoietic system diseases.2.Patients with other infectious diseases.3.Patients with severe kidney, liver and heart disease.4.Patients with severe mental illness or disturbance of consciousness.5.Patients who cannot understand the study protocol or participants after explanation.
Exclusion criteria (Criteria for judging that patients who have participated in the trial cannot continue to participate in the trial): 1.Serious adverse events occur that are not suitable for the next step of the trial.2.Poor compliance, affecting the efficacy judgment.3.Disease progression during treatment, need to change the treatment regimen.4.For any reason, the subject asked to withdraw from the trial
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method eurological function will be assessed by NIHSS 14 days NIHSS stroke scale includes 11 items such as consciousness, gaze, visual field, and movement,
- Secondary Outcome Measures
Name Time Method Activities of daily living will be assessed by BI 14 days The Barthel index score ranged from 0 to 100