NCT05595005终止不适用
Neural Bases of Post-stroke Emotion Perception Disorders
University Hospital, Lille2 个研究点 分布在 1 个国家目标入组 2 人开始时间: 2024年2月16日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 2
- 试验地点
- 2
- 主要终点
- BOLD signal when fear visual recognition
研究概览
简要总结
This monocentric physiological study will evaluate the neural bases of visual recognition of emotions in stroke patients vs. healthy controls using MRI (functional and structural connectivity) and EEG.
详细描述
This monocentric physiological study will evaluate the neural bases of visual recognition of emotions in stroke patients vs healthy controls (2 groups of 40 subjects). It will include functional MRI, structural MRI (disconnectome), EEG, and behavioral assessments of emotion recognition and executive functions.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Stroke group:
- •Man or Woman
- •Age 18-80y
- •Unique stroke, ischemic or hemorrhagic
- •at the chronic phase (< 6 months)
- •Written informed consent
- •subject having a social insurance
- •Subject who consent to complete all the study's experiments
- •Healthy controls group:
- •Man or Woman
- •Age 18-80y
- •No history of neurological or psychiatric disease.
排除标准
- •Stroke group
- •Subject who is unable to consent (due to dementia, severe aphasia, psychiatric disorder...)
- •History of other neurologic disorders
- •Significant le vel of depression or anxiety, assessed by the STAI and the BDI questionnaires
- •Non corrected visual loss
- •Subjects suffering from visual neglect (assessed by the Bells Test and a bisection test (20mm)
- •contra-indications to MRI
- •pregnant or breastfeeding woman
- •Women of childbearing age without effective contraception
- •Healthy controls group
- •Subject who is unable to consent (due to dementia, severe aphasia, psychiatric disorder...)
- •History of neurologic disorders
- •Significant level of depression or anxiety, assessed by the STAI and the BDI questionnaires
- •Non-corrected visual loss
- •contra-indications to MRI
- •pregnant or breastfeeding woman
- •Women of childbearing age without effective contraception
结局指标
主要结局
BOLD signal when fear visual recognition
时间窗: 1 day
Compare correlations of cerebral functional activations (BOLD) by fMRI between groups when stimulus = fear
次要结局
- BOLD signal when happiness visual recognition(1 day)
- Electrical connectivity (EEG) when fear visual recognition(1 day)
- Electrical connectivity (EEG) when fear happiness visual recognition(1 day)
- Electrical connectivity (EEG) when emotions auditory recognition(1 day)
- Relationship between behavioral performance and cerebral networks(1 day)
- Structural connectivity(1 day)
- Relationship between the behavioural performance in emotion recognition and executive functions(1 day)
- Relationship between emotional self-assessment and cerebral networks(1 day)
- Relationship between lesion characteristics and the behavioral performance in emotion recognition(1 day)
研究者
研究点 (2)
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