Hepatic Manifestations and Effect of Long COVID-19 on Patients With Chronic Liver Disease
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 65
- 试验地点
- 1
- 主要终点
- to evaluate the long term effect of COVID 19 on the liver
研究概览
简要总结
To measure the frequency of persistent liver dysfunction (raised liver enzymes, serum albumin, prothrombin time, etc) in recovered COVID -19 patients.
To compare the hepatic manifestations in post COVID -19 patients with and without liver disease
详细描述
The digestive tract, particularly the liver, has recently been reported to be affected by SARS-CoV-2. Although abnormal liver enzymes were regularly described as an extra-pulmonary clinical feature, and almost one half of patients experienced grades of hepatic injury. liver damage in patients with SARS infections was primarily manifested in the mild and moderate elevation of alanine and/or aspartate aminotransferases (ALT and AST) with some degree of hypoalbuminemia and hyperbilirubinemia during the early stage of the illness.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients previously diagnosed by COVID 19 eg : PCR and / or HRCT chest, lab of more than 1 month duration.
排除标准
- •Patients less than 18 y.
- •Patients with acute COVID 19.
结局指标
主要结局
to evaluate the long term effect of COVID 19 on the liver
时间窗: 1 month
to evaluate the changes in liver function (bilirubin ,liver enzymes , albumin , prothrombin time and INR in patients post COVID_19
次要结局
- : Effect of COVID 19 on diseased liver(1 month)
研究者
Huda Mokhtar Salim
clinical professor : Mohammed El _Taher Abdel_Rahman .
Assiut University