NCT04345640Unknown不适用
The Spectrum and Profile of COVID-19 Infection and Its Impact on Liver - The Pan Asia-Pacific Prospective Multi-centre Observational Study (APCOLIS STUDY)
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Spontaneous recovery or death in both groups
研究概览
简要总结
To address the existing deficiencies in the knowledge regarding liver involvement and spectrum of clinical presentation and the impact of COVID-19 infection in patients of liver disease was planned. The present study will be a hospital based and the cases of confirmed COVID-19 infection will be evaluated in relation to liver involvement irrespective of pre-existing liver disease. The primary objective was to address the clinical presentation, biochemical alteration and outcomes of COVID-19 infection in subjects with chronic hepatitis, cirrhosis in comparison to those having infection in the absence of pre-existing liver disease
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients of COVID-19 positive
- •Age 18-70 years
排除标准
- •No Valid consent
结局指标
主要结局
Spontaneous recovery or death in both groups
时间窗: 90 days
次要结局
- Improvement in severity assessment Indices Acute Physiology And Chronic Health Evaluation (APACHE) scores II in both groups(90 days)
- Duration of prior as well as present decompensation in both groups(90 days)
- Severity of prior as well as present decompensation in both groups(90 days)
- Improvement in severity assessment Indices Chronic Liver Failure-Sequential Organ Failure Assessment (CLIF SOFA) scores in both groups.(90 days)
- Improvement in severity assessment Indices Model for End Stage Liver Disease (MELD) scores in both groups(90 days)
- Improvement in severity assessment Indices Child-Turcotte-Pugh (CTP) scores in both groups(90 days)
- Improvement in severity assessment Indices Sequential Organ Failure Assessment (SOFA) scores in both groups(90 days)
研究者
研究点 (1)
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