Pathophysiology of neuropathic itch and pain - Chronic itch and pain on polyneuropathy

• Conditions: G62; G63; G64; G60; G61; Hereditary and idiopathic neuropathy; Inflammatory polyneuropathy; Other polyneuropathies; Polyneuropathy in diseases classified elsewhere; Other disorders of peripheral nervous system

• Registration Number: DRKS00015167
• Lead Sponsor: Westfälische Wilhelms-Universität Münster

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-07
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 225

Inclusion Criteria

Age =18, polyneuropathy, healthy matched controls

Exclusion Criteria

Taking antipruritic drugs, infection in the examination area

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The target value is the average nerve fiber density, IENFD, measured as fiber per millimeter. The following five groups will be compared regarding the IENFD:<br>1. pruritus and pain,<br>2. only pain,<br>3. only pruritus,<br>4. no pruritus and no pain,<br>5. healthy controls.<br>A Kruskal-Wallis test (non-parametric test) will be used as the statistical test.<br>During the examination, a biopsy will be taken to measure the nerve fiber density.<br>Furthermore, the patients will be asked to complete a questionnaire.

Secondary Outcome Measures

Name	Time	Method
QST: individual QST parameters - in comparison between the individual groups and in comparison to healthy controls as well as dependent on clinical symptoms<br>Electrical stimulation results (Threshold / VAS)<br>iontophoresis<br>Itching / pain intensities after stimulation / iontophoresis<br>Duration of itching / pain sensation<br>Flare reaction in patients with and without itching / itching compared to healthy controls as well as dependent on clinical symptoms (with / without pain etc) <br>CMP / CIM: endogenous inhibition (itching / pain) in patients with and without itching / itching compared to healthy controls as well as depending on clinical symptoms itching / pain