Ventilator - induced lung and systemic inflammation in children with healthy lungs: an explorative study
Withdrawn
- Conditions
- Ventilator - induced lung injury10038716
- Registration Number
- NL-OMON43254
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 35
Inclusion Criteria
• Written Informed consent obtained
Exclusion Criteria
• Patients with a history of allergic or respiratory diseases
• Known chromosomal disorder
• Known immunological disorders
• Recent episode of mechanical ventilation
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary endpoint is the level and time course of pulmonary inflammatory<br /><br>mediators including G-CSF, GM-CSF, IFN-, IFN-, IL-1, IL-1RA, IL-2, IL-2R, IL-4,<br /><br>IL-5, IL-6, IL7, IL-8, IL-10, IL-12, IL-13, IL-15, IL-17, TNF-alpha</p><br>
- Secondary Outcome Measures
Name Time Method <p>Level and time course of systemic inflammatory mediators (i.e. G-CSF, GM-CSF,<br /><br>IFN-, IFN-, IL-1, IL-1RA, IL-2, IL-2R, IL-4, IL-5, IL-6, IL7, IL-8, IL-10,<br /><br>IL-12, IL-13, IL-15, IL-17, TNF-alpha)<br /><br>Level and time course of pulmonary 1-antitrypsin concentrations<br /><br>Level and time course of pulmonary sRAGE concentrations<br /><br>Level and time course of systemic sRAGE concentrations</p><br>