Ventilation Inflammation Perfusion and Structure in Neonatal Lung patients

Completed

• Conditions: Bronchopulmonary dysplasia; underdeveloped lungs; 10028971

• Registration Number: NL-OMON54975
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 18

Inclusion Criteria

Premature: born before 28 weeks PMA, good enough clinical condition to undergo
MRI, parents manage Dutch language, informed consent by parents, at 34-40 weeks
still admitted at the Sophia Children's Hospital, (at risk for) severe BPD
according to NHI criteria (received at least 28 days of oxygen)
Non premature: born after a minimum of 37 weeks PMA, good enough clinical
condition to undergo MRI, parents manage Dutch language, informed consent by
parents

Exclusion Criteria

Premature: contraindication for MRI investigation
Non- premature: contraindicatie for MRI investigation, congenital
cardiovascular or pulmonary abnormalities, obtained mechanical ventilation

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main endpoint of this study is the technical qualitative assessment of the<br /><br>MRIs. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Second, the ability of the MRI protocol to detect airway and lung ventilation,<br /><br>inflammation, perfusion and structural changes. Third, the MRIs of prematurely<br /><br>born infants will be compared to the MRIs of non- premature patients without<br /><br>pulmonary disease. Lastly, the technical feasibility of MRI to detect cardiac<br /><br>structures will be assessed and the MRI findings will be compared to the EIT<br /><br>measurement. </p><br>