IRCT20200522047538N2招募中3 期
Evaluation of the effectiveness of metformin in WOMAC index of overweight knee osteoarthritis patients
适应症
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 88
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 50 years 至 75 years（—）
- 性别
- All
入选标准
- •Patients who, based on the radiography and ACR criteria, have knee osteoarthritis grades 2 & 3 according to the Kellgren and Lawrence criteria (Kellgren and Lawrence grade 2, the presence of osteophytes and joint space narrowing & grade 3 confirming the presence of more numbers of sclerosis and osteophyte).
- •50 to 75 years olds Man or woman
- •BMI body mass index (=24 kg/m2)
- •VAS Knee pain score= 2 on 10
- •Primary Osteoarthritis (not secondary OA due to trauma or inflammatory arthritis)
- •The person is willing and able to follow the study instructions and go to the clinic for a visit
- •No history of performing knee arthroscopy and injecting corticosteroids in the knee within less than 6 months from the beginning of the study
- •No allergy to any of the compounds used in the study
- •No history of severe trauma in the knee area
- •No history of other rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and others
- •No active malignancy, cancer or other life-destructive diseases and Type 1 or type 2 diabetes mellitus, hypoxic conditions (corpulmonary-congestive heart failure-acute MI-peripheral artery disease), uncontrolled high blood pressure
- •No Clinical manifestation of liver dysfunction or elevated alanine aminotransferase/aspartate ami- notransferase levels exceeding 2 times the upper limit of normal values
- •GFR glomerular filtration rate higher than ml/min/1.73m2-60
- •No history of systemic corticosteroids using
- •Not using of alcoholic substances
- •No history of Conditions affecting the absorption of oral drugs (e.g., post gastrectomy and malabsorption syndrome)
- •No history of using metformin in the last 30 days
排除标准
- •Injecting of corticosteroids in the knee within the study
- •Estimated glomerular filtration rate of less than 60 ml/min/1.73 m2;
- •Allergic to metformin hydrochloride;
- •Severe knee trauma during study
研究者
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