Clinical Impact of Red Cell Storage Age: Individual Patient Data Meta-Analysis of Four Recent Large Randomized Trials
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33,000
- 试验地点
- 1
- 主要终点
- All-cause mortality
研究概览
简要总结
The recent four RCTs evaluating effects of RBC storage age on morbidity and mortality found no statistically significant adverse effects of longer stored RBC compared to shorter storage ages. Unfortunately, none of these RCTs had sufficient numbers of subjects receiving RBC at either storage age extreme to identify consequences of RBC transfusion at these limits. To better investigate effects of RBC storage age on clinical outcomes, this study will perform secondary meta-analyses of merged common patient data elements -individual patient data (IPD) meta-analysis (IPDMA) - from the nearly 33,000 subjects enrolled in the four RCTs.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Received at least one RBC transfusion
- •>=18 years of age
排除标准
- 未提供
结局指标
主要结局
All-cause mortality
时间窗: 28 days after transfusion
Estimate the effect of transfused RBC storage-age on time to all-cause mortality
Hospital length of stay
时间窗: after transfusion through 28 days
Estimate the effect of transfused RBC storage-age on hospital stay
次要结局
- All-cause mortality at 28 days for long-storage(28 days after transfusion)
- 28 day mortality for short-storage(28 days after transfusion)