Effect Nitrous Oxide On Acute Postoperative Pain and Opioid Consumption and Chronic Pain After Inguinal Hernia Repair Surgery
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Nitrous oxide and opioid consumption
研究概览
简要总结
To compare postoperative pain, opioid consumption and chronic pain in patients undergoing to hernia repair surgery after receiving nitrous oxide or oxygen during the general anesthesia.
详细描述
The study is prospective and double blind. In the clinic, patients undergoing inguinal hernia surgery that meet the criteria for inclusion into the study and agreed to participate in the study will be randomized into two groups. In the first group of patients will receive Nitrous Oxide and In the second group of patients will receive oxygen during the general anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 to 65 years old at time of the first procedure
- •American Society of Anesthesiologists physical status I or II
- •Inguinal hernia repair surgery undergoing the general anesthesia
排除标准
- •Neuropathic disease
- •Chronic opioid users
- •Contraindication for Nitrous Oxide receive
- •Consent will not be obtained patient
- •Psychiatric disorders
- •Current or recent drug abuse (within past 6 months).
研究组 & 干预措施
Nitrous oxide
Subjects will receive General anesthesia with Nitrous Oxide.
干预措施: Nitrous Oxide (Drug)
Oxygen
Subjects will receive General anesthesia with oxygen.
干预措施: oxygen (Other)
结局指标
主要结局
Nitrous oxide and opioid consumption
时间窗: 4 hours after surgery
The effect of 70% N20/30% O2 on post inguinal hernia repair procedure in decrease in opioid consumption.
Nitrous oxide and chronic pain
时间窗: 30 days post operative
The effect of 70% N20/30% O2 on post inguinal hernia repair procedure in prevention of chronic pain.
次要结局
- smoking and chronic pain(30 days post operative)
- smoking and post operative pain(4 hours after surgery)
研究者
Alparslan Turan
PI
The Cleveland Clinic