Intraoperative Nitrous Oxide and Postoperative Pain for Patients With Current Opioid Treatment
- Conditions
- Chronic Pain
- Registration Number
- NCT00210158
- Lead Sponsor
- Institut Bergonié
- Brief Summary
Peroperative opioids are known to induce N-Methyl-D-Aspartate dependent enhancement of postoperative hyperalgesia. For patients with current opioid treatment, these phenomena could be exagerated and could produce greater postoperative opioid consumption and higher pain score. Since Nitrous oxide has anti- N-Methyl-D-Aspartate properties, the aim of this study was to evaluate, in patients with current opioid treatment, the effects of peroperative Nitous oxide on postoperative opioid consumption and pain score, after vertebroplasty.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 39
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Post-operative Morphine Consumption Between surgery and up to 48 hours Morphine consumption (mg) during PCA (Patient Controlled Analgesia)
- Secondary Outcome Measures
Name Time Method Proportion of Participants With Post-operative Pain Between surgery and up to 48 hours Pain is measured using a visual analog scale (VAS), ranging from 0 (no pain) to 100 (worst pain ever).
A participant is considered to have pain if VAS score is \>= 40.
Trial Locations
- Locations (1)
Institut Bergonié - Centre Régional de Luttre Contre le Cancer DE Bordeaux et du Sud Ouest
🇫🇷Bordeaux, France
Institut Bergonié - Centre Régional de Luttre Contre le Cancer DE Bordeaux et du Sud Ouest🇫🇷Bordeaux, France