Identification of Factors That Predict Early Haemodialysis Arteriovenous Fistula Failure
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Arteriovenous Fistula
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
- Enrollment
- 105
- Locations
- 1
- Primary Endpoint
- Identification of the pre/perioperative factors that predict early AVF failure (eAVFF)
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Arteriovenous fisutla (AVF) is the vascular access of choice for hemodialysis but has a high early failure (eAVFF) rate. eAVFF can be defined as thrombosis/stenosis and Doppler ultrasound (DUS)-based failure-to-mature parameters such as postoperative blood flow (PostQa) < 500 ml/min, AVF-vein diameter (PostVD) < 5 mm, and AVF-vein depth (PostVDepth) ≥ 6 mm. We explored whether common risk factors for eAVFF could predict these eAVFF parameters and venous distensibility: the latter is largely overlooked as a potential eAVFF parameter.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult patients (≥ 18 years)
- •Patients who had undergone distal (radioradial and radiocephalic) or proximal arteriovenous fistula (AVF) access creation surgery between 2016 and 2021 at the CHR Metz-Thionville.
- •Patients who underwent preoperative and postoperative Doppler ultrasound (DUS) ≤ 4 months after surgery.
- •Patients with central venous catheter (CVC) at surgery
Exclusion Criteria
- •Patients using the fistula for intermittent plasmapheresis
- •Patients with a radiobasilic AVF or arteriovenous graft
Outcomes
Primary Outcomes
Identification of the pre/perioperative factors that predict early AVF failure (eAVFF)
Time Frame: up to 3 months after AVF creation
Comparison of preoperative and intraoperative results according to composite factors of arteriovenous fistula failure: Qa blood flow \< 500 ml/min, postoperative venous internal diameter PostVD \< 5 mm; complications: presence of stenosis, presence of thrombosis; AVF vein depth (external diameter) (PostVDepth) ≥ 6. The following variables were compared between groups: age (years) , sex (Man/Women), body mass index (kg/m2), Comorbidities \[Diabetes mellitus (yes/no), obesity (yes/no)\], Preoperative hemoglobin (g/dl); locoregional anesthesia (yes/no), Central Venous Catether (CVC) use (yes/no); CVC use on same side as AVF (yes/no); AVF on left side of body (yes/no); Distal AVF location (yes/no); Preop AVF vessel diameter (artery and vein; mm).
Secondary Outcomes
- Identification of the pre/perioperative factors that predict the early postoperative AVF blood flow (PostQa)(up to 3 months after AVF creation)
- Identification of the pre/perioperative factors that predict the early postoperative venous internal diameter (PostVD)(up to 3 months after AVF creation)
- Identification of the pre/perioperative factors that predict the early postoperative AVF stenosis and/or thrombosis(up to 3 months after AVF creation)
- Identification of the pre/perioperative factors that predict the early postoperative skin to AVF distance(up to 3 months after AVF creation)