The Effects of Dexmedetomidine and Tramadol on Extubation Quality and Postoperative Pain and Agitation in Pediatric Patients Undergoing Adenotonsillectomy Surgery
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 60
研究概览
简要总结
Post-operative Riker sedation agitation scale was significantly lower in dexmedetomidine group than in tramadol group at post-operative 1st, 15th and 30th minutes. Similarly, pain point scale was significantly lower in dexmedetomidine group than in tramadol group at post-operative 1st, 15th and 30th minutes. Serious adverse events such as respiratory depression, hemodynamic instability, hypotension and bradycardia were not observed in any patient. In addition, extubation time was significantly longer in dexmedetomidine group compared to tramadol group. However, not breathing, coughing-bucking and desaturation after extubation were significantly more frequent with tramadol compared to with dexmedetomidine. In conclusion, dexmedetomidine was more effective and safer than tramadol for controlling post-operative pain and agitation in children patients undergoing adenotonsillectomy surgery with sevoflurane. Although it was associated with longer extubation time, dexmedetomidine provided better extubation quality compared to tramadol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 2 Years 至 9 Years（—）
- 性别
- All
入选标准
- •A total of 60 children patients undergoing adenotonsillectomy surgery, aged between 2- 9 years and with American Society of Anesthesiologist (ASA) grades I or II, were included in this randomized study.
排除标准
- •Patients with a history of any chronic disease, ASA grades III or higher, blood pressure <100/50 mm Hg, heart rate < 60/bpm and known any allergy to study medications were excluded from the study.