Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 43
- Locations
- 2
- Primary Endpoint
- Isotope absorption into blood stream
Study Overview
Brief Summary
The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.
Detailed Description
The aim of the study is to determine how iron metabolism in subjects with infectious diseases (malaria, hookworm or S. haematobium) differs while infected and after treatment, i.e. the same individuals will be restudied while free of infection.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 12 Years to 16 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Children aged 12 to 16 years
- •Body weight > 30 kg
- •no chronic medical illnesses
- •no intake of vitamin/mineral supplements 2 weeks before the study and until the last blood drawing
- •For each of the 4 arms the respective disease needs to be present (symptomatic malaria, asymptomatic malaria, hookworm infection, S. haematobium infection) without any other concurrent infection
Exclusion Criteria
- Not provided
Arms & Interventions
Symptomatic malaria infection
Intervention: Fe-57 orally, Fe-58 intravenously (Dietary Supplement)
Asymptomatic malaria infection
Intervention: Fe-57 orally, Fe-58 intravenously (Dietary Supplement)
Hookworm infection
Intervention: Fe-57 orally, Fe-58 intravenously (Dietary Supplement)
Schistosoma haematobium infection
Intervention: Fe-57 orally, Fe-58 intravenously (Dietary Supplement)
Outcomes
Primary Outcomes
Isotope absorption into blood stream
Time Frame: Day 43
Secondary Outcomes
- Biochemical parameters of iron status and infection(Day 43)
- Isotope incorporation into erythrocytes(Day 43)
Investigators
Prof. Michael B. Zimmermann
Prof
Swiss Federal Institute of Technology