Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma
Not Applicable
Completed
- Conditions
- Hookworm InfectionsSchistosoma HaematobiumMalaria, Falciparum
- Interventions
- Dietary Supplement: Fe-57 orally, Fe-58 intravenously
- Registration Number
- NCT01163877
- Lead Sponsor
- Swiss Federal Institute of Technology
- Brief Summary
The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.
- Detailed Description
The aim of the study is to determine how iron metabolism in subjects with infectious diseases (malaria, hookworm or S. haematobium) differs while infected and after treatment, i.e. the same individuals will be restudied while free of infection.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 43
Inclusion Criteria
- Children aged 12 to 16 years
- Body weight > 30 kg
- no chronic medical illnesses
- no intake of vitamin/mineral supplements 2 weeks before the study and until the last blood drawing
- For each of the 4 arms the respective disease needs to be present (symptomatic malaria, asymptomatic malaria, hookworm infection, S. haematobium infection) without any other concurrent infection
Exclusion Criteria
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Hookworm infection Fe-57 orally, Fe-58 intravenously - Symptomatic malaria infection Fe-57 orally, Fe-58 intravenously - Asymptomatic malaria infection Fe-57 orally, Fe-58 intravenously - Schistosoma haematobium infection Fe-57 orally, Fe-58 intravenously -
- Primary Outcome Measures
Name Time Method Isotope absorption into blood stream Day 43
- Secondary Outcome Measures
Name Time Method Biochemical parameters of iron status and infection Day 43 Isotope incorporation into erythrocytes Day 43
Trial Locations
- Locations (1)
Taabo Cité Hospital
🇨🇮Taabo, Côte D'Ivoire