NCT01163877已完成不适用
Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma.
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 43
- 试验地点
- 2
- 主要终点
- Isotope absorption into blood stream
研究概览
简要总结
The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.
详细描述
The aim of the study is to determine how iron metabolism in subjects with infectious diseases (malaria, hookworm or S. haematobium) differs while infected and after treatment, i.e. the same individuals will be restudied while free of infection.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 12 Years 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children aged 12 to 16 years
- •Body weight > 30 kg
- •no chronic medical illnesses
- •no intake of vitamin/mineral supplements 2 weeks before the study and until the last blood drawing
- •For each of the 4 arms the respective disease needs to be present (symptomatic malaria, asymptomatic malaria, hookworm infection, S. haematobium infection) without any other concurrent infection
排除标准
- 未提供
研究组 & 干预措施
Symptomatic malaria infection
Other
干预措施: Fe-57 orally, Fe-58 intravenously (Dietary Supplement)
Asymptomatic malaria infection
Other
干预措施: Fe-57 orally, Fe-58 intravenously (Dietary Supplement)
Hookworm infection
Other
干预措施: Fe-57 orally, Fe-58 intravenously (Dietary Supplement)
Schistosoma haematobium infection
Other
干预措施: Fe-57 orally, Fe-58 intravenously (Dietary Supplement)
结局指标
主要结局
Isotope absorption into blood stream
时间窗: Day 43
次要结局
- Biochemical parameters of iron status and infection(Day 43)
- Isotope incorporation into erythrocytes(Day 43)
研究者
Prof. Michael B. Zimmermann
Prof
Swiss Federal Institute of Technology
研究点 (2)
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