Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma

Not Applicable

Completed

• Conditions: Hookworm Infections; Schistosoma Haematobium; Malaria, Falciparum

• Registration Number: NCT01163877
• Lead Sponsor: Swiss Federal Institute of Technology

Brief Summary

The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.

Detailed Description

The aim of the study is to determine how iron metabolism in subjects with infectious diseases (malaria, hookworm or S. haematobium) differs while infected and after treatment, i.e. the same individuals will be restudied while free of infection.

Study Timeline

• Study Start: 2010-04
• Study First Submitted: 2010-07-14
• Study First Submitted QC: 2010-07-15
• Study First Posted: 2010-07-16
• Primary Completion: 2013-09
• Study Completion: 2013-09
• Status Verified: 2013-10
• Last Update Submitted: 2013-10-11
• Last Update Posted: 2013-10-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

• Children aged 12 to 16 years
• Body weight > 30 kg
• no chronic medical illnesses
• no intake of vitamin/mineral supplements 2 weeks before the study and until the last blood drawing
• For each of the 4 arms the respective disease needs to be present (symptomatic malaria, asymptomatic malaria, hookworm infection, S. haematobium infection) without any other concurrent infection

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Isotope absorption into blood stream	Day 43

Secondary Outcome Measures

Name	Time	Method
Isotope incorporation into erythrocytes	Day 43
Biochemical parameters of iron status and infection	Day 43

Trial Locations

Locations (1)

Taabo Cité Hospital; 🇨🇮 Taabo, Côte D'Ivoire