Identification of the mechanisms of 5-fluorouracil (5-FU)-induced Gastrointestinal (GI) toxicity in human colo
- Conditions
- EN: Gastrointestinal, 5-fluorouracil, Adverse effects, ToxicityNL: Gastrointestínaal, 5-fluorouracil, Schadelijke bijwerkingen, Toxiciteit
- Registration Number
- NL-OMON26903
- Lead Sponsor
- Maastricht University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Metastatic breast cancer patients receiving capecitabine monotherapy as their regular treatment;
- Age above 18 years old;
Exclusion Criteria
- Alcohol abuse up to 6 months before participation in this research, i.e. more than 4 drinks on any single day and more than 14 drinks per week for men and more than 3 drinks on any single day and more than 7 drinks per week for women
- Current presence of any diseases related to the gastrointestinal tract
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in the whole genome transcriptomic response after exposure to 5-FU in colon epithelium.
- Secondary Outcome Measures
Name Time Method Molecular markers associated to 5-FU induced toxicity in the colon such as citrulline and calprotectin.