Estrogen Hormone Protocol
- Conditions
- Alzheimer Disease
- Registration Number
- NCT00000177
- Lead Sponsor
- National Institute on Aging (NIA)
- Brief Summary
Estrogen is a hormone that is dominant in the female reproductive system. In women, most estrogen is produced by the ovaries. Men produce estrogen by converting testosterone into estrogen. Because this hormone also has many beneficial effects on brain cells, it currently is being studied as a treatment for Alzheimer's disease. The enzyme that forms the neurotransmitter acetylcholine is promoted in the presence of estrogen. Several very small clinical studies have demonstrated improvement in cognitive function and mood measures in women with Alzheimer's disease who take estrogen.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 120
- Women with a diagnosis of Alzheimer's disease who currently are not taking estrogen replacement therapy, who have had a hysterectomy, and who are in stable general health.
- Patients with an uncontrolled health problem, such as untreated high blood pressure or thyroid disease.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (25)
Johns Hopkins University
๐บ๐ธBaltimore, Maryland, United States
Washington University
๐บ๐ธSt. Louis, Missouri, United States
University of Pennsylvania
๐บ๐ธPhiladelphia, Pennsylvania, United States
University Hospitals of Cleveland
๐บ๐ธCleveland, Ohio, United States
Baylor College of Medicine
๐บ๐ธHouston, Texas, United States
University of Washington
๐บ๐ธSeattle, Washington, United States
Burke Medical Research Institute
๐บ๐ธWhite Plains, New York, United States
University of Pittsburgh
๐บ๐ธPittsburgh, Pennsylvania, United States
University of Texas
๐บ๐ธDallas, Texas, United States
University of South Florida
๐บ๐ธTampa, Florida, United States
University of Alabama, Birmingham
๐บ๐ธBirmingham, Alabama, United States
University of California, San Diego
๐บ๐ธSan Diego, California, United States
Mayo Clinic Jacksonville
๐บ๐ธJacksonville, Florida, United States
Emory University
๐บ๐ธAtlanta, Georgia, United States
Rush Presbyterian St. Luke's Medical Center
๐บ๐ธChicago, Illinois, United States
Southern Illinois University
๐บ๐ธSpringfield, Illinois, United States
Massachusetts General Hospital
๐บ๐ธBoston, Massachusetts, United States
Indiana University Medical Center
๐บ๐ธIndianapolis, Indiana, United States
University of Kentucky
๐บ๐ธLexington, Kentucky, United States
University of Minnesota
๐บ๐ธMinneapolis, Minnesota, United States
New York University Medical Center
๐บ๐ธNew York, New York, United States
Mayo Clinic
๐บ๐ธRochester, Minnesota, United States
Mount Sinai School of Medicine
๐บ๐ธNew York, New York, United States
Columbia Presbyterian Medical Center
๐บ๐ธNew York, New York, United States
University of Kansas Medical Center
๐บ๐ธKansas City, Kansas, United States