Clinical Features and Outcomes of CBP Versus Non-CBP in Septic Children

Recruiting

• Conditions: Sepsis; Children, Only
• Interventions: Procedure: CBP

• Registration Number: NCT04794595
• Lead Sponsor: Children's Hospital of Fudan University

Brief Summary

The effect of continuous blood purification (CBP) in children is unclear. Also, the timing of early application is still being explored. In this study, we need to explore the efficacy and the timing of application of CBP in children with sepsis or septic shock.

Detailed Description

Early intervention of CBP can remove inflammatory factors in patients with sepsis and reduce the damage of inflammatory factors to organs; at the same time, it can also promote the body's immune response, significantly improve immune dysfunction, and restore the body's immune balance. However, the timing of early application of CBP in childhood sepsis is still unclear. Therefore, it is necessary to further explore the treatment and prognosis of this technology in the early treatment of sepsis.

Study Timeline

• Study Start: 2020-12-01
• Study First Submitted: 2021-03-09
• Study First Submitted QC: 2021-03-09
• Study First Posted: 2021-03-12
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-18
• Last Update Posted: 2025-02-20
• Primary Completion: 2025-12-30
• Study Completion: 2026-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Age of 29d to 18 years old;
• Children diagnosed with sepsis requiring blood purification.

Exclusion Criteria

• with a history of a duration of PICU stay <24 h
• active bleeding, including cerebral hemorrhage

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
sepsis group with CBP	CBP	The child with sepsis should be treated with CBP， but could not receive this treatment for various reasons

Primary Outcome Measures

Name	Time	Method
survival rate	28 days after hospital discharge	The survival rate of children in 28 days after hospital discharge

Secondary Outcome Measures

Name	Time	Method
The creatinine level of non-survival children with sepsis	28 days after hospital discharge	The creatinine level of non-survival children with sepsis in 28 days after hospital discharge

Trial Locations

Locations (1)

Children'S Hospital of Fudan University; 🇨🇳 Shanghai, Shanghai, China