Influence of hemodilution on the microcirculation during cardiac surgery with heart-lung machine
Recruiting
- Conditions
- Microcirculation
- Registration Number
- DRKS00026185
- Lead Sponsor
- Robert-Bosch-Krankenhaus
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Age at least 18 years or older
Cardiac surgery with heart-lung-maschine
Surgery in normothermia
Signed consent form
Exclusion Criteria
No access to the sublingual mucosa, for example due to previous injuries or surgery in this area
Emergency surgery
Patients with endocarditis
Pregnancy
Re-operations
Known preoperative renal insufficiency or
Creatinine level >1.3 mg/dl
Multimorbid patients
Preoperative anemia
Procedures with minimized heart-lung machine
No informed consent or withdrawal of signed consent
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method In the statistical evaluation, both groups will be compared with regard to the following parameters obtained by measuring the sublingual microcirculation:<br><br>- Total vessel density<br>- Perfused vessel density<br>- Functional capillary density<br>- Microvascular flow index<br>- Erythrocyte velocity<br><br>Sublingual microcirculation is measured before extracorporal circulation, after induction of cardiac arrest and after aortic cross clamping.<br><br><br>The null hypothesis of the study is:<br><br>Haemodilution during cardiac surgery with the aid of extracorporal circulation has no effect on the sublingual microcirculation.
- Secondary Outcome Measures
Name Time Method Correlation between cardiac output, mean arterial pressure, indexed oxygen supply during extracorporeal circulation and sublingual microcirculation. Furthermore, a possible correlation between acute renal failure up to 48 hours postoperatively according to Kidney Disease: Improve Global Outcome criteria and the sublingual microcirculation during extracorporeal circulationwill be investigated.