Perioperative Challenges: Does Smoking Compromise High-Flow Nasal Oxygen Efficacy in Obese Men?
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- the safe apnoea times
研究概览
简要总结
There is a risk of airway-related incidents during anaesthesia associated with obesity. High-flow nasal oxygen is advocated for perioperative preoxygenation in obese patients to reduce airway adverse reactions. However, there have been no reports on whether smoking behaviors have an impact on obese men's Apnoeic oxygenation with high-flow nasal.This study compared the effects of smoking on the duration of safe apnoea times in obese males.
详细描述
All patients were were divided into two groups based on smoking status: smokers(S groups), and never smokers(NS groups). Those in the smoking group were current smokers, while those in the nonsmoking group had never smoked. Both groups of patients were induced with intravenous anesthesia and received 5 minutes of high flow nasal oxygen (60 L min) prior to induction.After induction of anaesthesia, the patients were apnoeic until peripheral oxygen saturation decreased to 95 %.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
A total of 60 male obese patients undergoing elective non-thoracic surgery were divided into two groups (n=30) based on smoking status: smokers(S groups), and never smokers(NS groups). Those in the smoking group were current or past smokers, while those in the nonsmoking group had never smoked.
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Participants ranged in age from 18 to 80 with BMI≥30 kg/m
- •Participants are male obese patients undergoing elective non-thoracic surgery
- •Exclusion Criteria :
- •patients were kept awake during the intubation due to cervical spine pathology.
- •Patients with unstable hemodynamics.
- •Patients with airway inflammatory diseases, including asthma, chronic obstructive pulmonary disease (COPD), lung cancer, pulmonary fibrosis and cystic fibrosis.
- •Patients with upper respiratory infection and nasal blockage.
- •Patients with Hypersensitivity to the drug.
排除标准
- 未提供
结局指标
主要结局
the safe apnoea times
时间窗: 5-minute
Investigators will record the time of oxygen saturation drop to 95 % during intubation.
次要结局
- the Pao2 levels(5-minute)