Assessment of Endocan Serum Levels in Patients With Behcet Disease: Relation to Clinical Parameters and Disease Status
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- the Behcet's disease current activity form (BDCAF)
研究概览
简要总结
The aim of our study was to assess serum endocan levels in patients with Behcet disease and to correlate it with various disease clinical and laboratory parameters of disease activity as well as carotid intima media thickness.
详细描述
This study will be carried out on two groups:
• Group (I): Forty two patients diagnosed to have Behcets disease fulfilling the International Criteria for BD .
Group (II): including 42 age and sex matching healthy volunteers as control group.
(A) Clinical evaluation
- Complete history taking.
- Thorough clinical examination including opthalmologic evaluation .
- Disease activity using The Behcet's disease current activity form (BD-DAF) . (B) Laboratory assessment:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients with Behcets disease fulfilling the International Criteria for BD .
排除标准
- •infection
- •malignancy
- •other connective tissue disease
- •chronic liver disease
- •chronic kidney disease
- •Diabetes mellitus
- •hypertension
- •hyperlipidemia
结局指标
主要结局
the Behcet's disease current activity form (BDCAF)
时间窗: : through study completion, an average of 6 months
One point is given to the presence of different organ involvement over the 4 weeks prior to assessment as follows: headache, mouth ulcers, genital ulcers, skin lesions , joint involvement , gastrointestinal symptoms , eye involvement , nervous system involvement , and major vessel involvement.The total score will be out of 12 and higher score indicates worse outcome. we will assess the relation between serum endocan level and BDCAF
Erythrocyte sedimentation rate (ESR)
时间窗: : through study completion, an average of 6 months
ESR measured in mm/1st hour by westergren method. we will assess the relation between serum endocan level and ESR
C reactive protein (CRP)
时间窗: : through study completion, an average of 6 months
CRP measured in mg/L using nephlometry. we will assess the relation between serum endocan level and CRP
carotid intima media thickness
时间窗: : through study completion, an average of 6 months
Color Doppler ultrasonography was performed for both common carotid arteries in a longitudinal orientation and measured with millimeter
次要结局
未报告次要终点
研究者
Waleed Ahmed Salaheldeen Hassan
Assistant professor
Benha University