Effect of Two Doses of Coenzyme Q10 on Seminal Fluid and Semen Antioxidant Status

Not Applicable

Completed

• Conditions: Male Infertility
• Interventions: Dietary Supplement: Coenzyme Q10 200; Dietary Supplement: Coenzyme Q10 400

• Registration Number: NCT03850561
• Lead Sponsor: University of Sumer

Brief Summary

The study was conducted to assess the impact of two doses of coenzyme Q10 on seminal fluid parameters and antioxidant status in infertile men.

Detailed Description

The aim of this study was to assess the impact of two doses of coenzyme Q10 on seminal fluid parameters and antioxidant status in infertile men with idiopathic oligoasthenoteratospermia.

Study Timeline

• Study Start: 2018-06-01
• Primary Completion: 2018-11-20
• Study Completion: 2019-01-25
• Status Verified: 2019-02
• Study First Submitted: 2019-02-20
• Study First Submitted QC: 2019-02-20
• Last Update Submitted: 2019-02-20
• Study First Posted: 2019-02-22
• Last Update Posted: 2019-02-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 65

Inclusion Criteria

• History of infertility of at least 12 months despite regular unprotected intercourse.

Oligoasthenoteratospermia was diagnosed by semen analysis showing abnormal sperm concentration (<15 million/ml), progressive motility (<32%), total motility (<40%) and morphology (<30% WHO criteria) as defined by WHO manual for semen analysis 2010

Exclusion Criteria

• Azoospermia,
• Varicocele,
• Genital tract infection,
• Cryptorchidism,
• Testicular trauma or scrotal surgery,
• Endocrine disorder,
• Systemic illness,
• Smoking
• The presence of female factor

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Coenzyme Q10 200	Coenzyme Q10 200	Coenzyme Q10 200mg/day for 3 months
Coenzyme Q10 400	Coenzyme Q10 400	Coenzyme Q10 400mg/day for 3 months

Primary Outcome Measures

Name	Time	Method
Semen volume (WHO 2010 guidelines)	3 months	Semen volume in ml
Sperm motility in semen (WHO 2010 guidelines)	3 months	Sperm motility (%)
Sperm morphology in semen (WHO 2010 guidelines)	3 months	Normal sperm morphology (%)
Sperm concentration in semen (WHO 2010 guidelines)	3 months	Sperm concentration in million/ml
Seminal plasma TAC	3 months	Seminal plasma total antioxidant capacity in mmol/ml
Seminal plasma SOD	3 months	Superoxide dismutase in U/ml
Seminal plasma CAT	3 months	Seminal plasma catalase in U/ml

Trial Locations

Locations (1)

Fertility Unit, Babyl; 🇮🇶 Hilla, Iraq