Effect of Two Doses of Coenzyme Q10 on Seminal Fluid and Semen Antioxidant Status
- Conditions
- Male Infertility
- Registration Number
- NCT03850561
- Lead Sponsor
- University of Sumer
- Brief Summary
The study was conducted to assess the impact of two doses of coenzyme Q10 on seminal fluid parameters and antioxidant status in infertile men.
- Detailed Description
The aim of this study was to assess the impact of two doses of coenzyme Q10 on seminal fluid parameters and antioxidant status in infertile men with idiopathic oligoasthenoteratospermia.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 65
- History of infertility of at least 12 months despite regular unprotected intercourse.
Oligoasthenoteratospermia was diagnosed by semen analysis showing abnormal sperm concentration (<15 million/ml), progressive motility (<32%), total motility (<40%) and morphology (<30% WHO criteria) as defined by WHO manual for semen analysis 2010
- Azoospermia,
- Varicocele,
- Genital tract infection,
- Cryptorchidism,
- Testicular trauma or scrotal surgery,
- Endocrine disorder,
- Systemic illness,
- Smoking
- The presence of female factor
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Sperm motility in semen (WHO 2010 guidelines) 3 months Sperm motility (%)
Sperm morphology in semen (WHO 2010 guidelines) 3 months Normal sperm morphology (%)
Semen volume (WHO 2010 guidelines) 3 months Semen volume in ml
Sperm concentration in semen (WHO 2010 guidelines) 3 months Sperm concentration in million/ml
Seminal plasma TAC 3 months Seminal plasma total antioxidant capacity in mmol/ml
Seminal plasma SOD 3 months Superoxide dismutase in U/ml
Seminal plasma CAT 3 months Seminal plasma catalase in U/ml
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Fertility Unit, Babyl
🇮🇶Hilla, Iraq
Fertility Unit, Babyl🇮🇶Hilla, Iraq