Impact of Coenzyme Q10 and Selenium on Seminal Fluid and Semen Antioxidant Status
Not Applicable
Completed
- Conditions
- Male Infertility
- Registration Number
- NCT03834831
- Lead Sponsor
- University of Sumer
- Brief Summary
The study was conducted to assess the impact of coenzyme Q10 and selenium on seminal fluid parameters and antioxidant status in infertile men.
- Detailed Description
The aim of this study was to assess the impact of coenzyme Q10 and selenium on seminal fluid parameters and antioxidant status in infertile men with idiopathic oligoasthenoteratospermia.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 70
Inclusion Criteria
- History of infertility of at least 12 months despite regular unprotected intercourse.
- Oligoasthenoteratospermia was diagnosed by semen analysis showing abnormal sperm concentration (<15 million/ml), progressive motility (<32%), total motility (<40%) and morphology (<30% WHO criteria) as defined by WHO manual for semen analysis 2010
Exclusion Criteria
- Azoospermia,
- Varicocele,
- Genital tract infection,
- Cryptorchidism,
- Testicular trauma or scrotal surgery,
- Endocrine disorder,
- Systemic illness,
- Smoking
- The presence of female factor
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Semen volume (WHO 2010 guidelines) 3 months Semen volume in ml
Sperm morphology in semen (WHO 2010 guidelines) 3 months Normal sperm morphology (%)
Seminal plasma TAC (Colorimetric assays) 3 months Seminal plasma total antioxidant capacity in mmol/ml
Seminal plasma CAT (Colorimetric assays) 3 months Seminal plasma catalase in U/ml
Sperm concentration in semen (WHO 2010 guidelines) 3 months Sperm concentration in million/ml
Sperm motility in semen (WHO 2010 guidelines) 3 months Sperm motility (%)
Seminal plasma SOD (Colorimetric assays) 3 months Superoxide dismutase in U/ml
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Fertility Unit, Babyl
🇮🇶Hilla, Iraq
Fertility Unit, Babyl🇮🇶Hilla, Iraq