Impact of Number of Rank of B-lactam Antibiotics on Emergence on Multidrug Resistant Bacteria

• Conditions: Resistant Infection; Antibiotic Resistant Infection; Beta Lactam Resistant Bacterial Infection; Bacterial Resistance
• Interventions: Procedure: number of Beta lactam class prescription for the same infection

• Registration Number: NCT03752476
• Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Brief Summary

This study evaluates the impact of rank of Beta lactam antibiotics on emergence of mutlidrug resistant bacteria colonization in intensive care

It's retrospective case controle study. Cases are colonized patient by multidrug resistant bacteria hospitalized in intensive care during the fist hospitalization in intensive care. Temoin are patients with the same characteristics than case but no colonized by multidrug resistant bacteria.

Detailed Description

The emergence of multidrug resistant is a wordwide problem. B lactam resistant increase. The antibiotic prescription impact this problem.

B lactam antibiotic is prescribed everyday in intensive care unit. The switch of antibiotic is common. Antibiotic classes inclue a lot of rank with different spectum that impact the occurrence of resistant.

Study Timeline

• Status Verified: 2018-11
• Study First Submitted: 2018-11-21
• Study First Submitted QC: 2018-11-21
• Last Update Submitted: 2018-11-21
• Study First Posted: 2018-11-26
• Last Update Posted: 2018-11-26
• Study Start: 2019-01-01
• Primary Completion: 2019-05-01
• Study Completion: 2019-05-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1300

Inclusion Criteria

• all patient hospitalized more than 48 hours in intensive care unit in Besançon between january 2016 and december 2017

Exclusion Criteria

• patient under guardianship
• patient allergic to Beta lactam
• colonization with mutidrug resistant the first week of hospitalization in intensive care unit

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
case	number of Beta lactam class prescription for the same infection	Patients are colonized patient by antimicrobial bacteria hospitalized in intensive care during the fist hospitalization in intensive care during 2016-2017.
control	number of Beta lactam class prescription for the same infection	Patients aren't colonized patient by antimicrobial bacteria hospitalized in intensive care during the fist hospitalization in intensive care during 2016-2017.

Primary Outcome Measures

Name	Time	Method
number of Beta lactam class prescription	3 months