A Phase III Study Comparing Adjuvant Chemotherapy Consisting of Capecitabine/Oxaliplatin Versus Surgery Alone in Patients With Stage II (T1N2, T2N1, T3N0), IIIa (T2N2, T3N1, T4N0) and IIIb (T3N2) Gastric Adenocarcinoma
Overview
- Phase
- Phase 3
- Intervention
- Capecitabine
- Conditions
- Gastric Cancer
- Sponsor
- Hoffmann-La Roche
- Enrollment
- 1035
- Primary Endpoint
- Disease-free survival rate
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
This study will compare capecitabine/oxaliplatin as adjuvant chemotherapy versus observation alone in chemotherapy-naive participants who have undergone potentially curative resection for gastric cancer. Participants will be randomized to either the chemotherapy arm or the observation arm. Capecitabine will be administered orally, 1000 milligrams per meter-squared (mg/m^2) twice daily (BID) on Days 1 to 15 of a 3-week cycle, for 8 cycles, and oxaliplatin will be administered as an intravenous (IV) infusion, 130 mg/m^2 every 3 weeks for 8 cycles. The anticipated time on study treatment in 6 months and the target sample size is 1024 individuals.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult participants greater than or equal to (\>=) 18 years of age
- •Gastric adenocarcinoma, Stage II, IIIa or IIIb
- •Potentially curative resection of tumor within 6 weeks prior to randomization
- •Previously untreated with chemotherapy or radiotherapy
Exclusion Criteria
- •Serious concomitant medical illnesses that would limit life expectancy to less than (\<) 5 years
- •Sexually active males and females (of childbearing potential) unwilling to practice contraception during the study
- •Any evidence of metastatic disease (including presence of tumor cells in the ascites)
Arms & Interventions
Capecitabine + Oxaliplatin
Patients will receive oral capecitabine (1000 mg/m\^2 BID on Days 1 to 15 ) plus IV oxaliplatin (130 mg/m\^2 on Day 1) during each 3-week cycle for up to 8 cycles (6 months).
Intervention: Capecitabine
Capecitabine + Oxaliplatin
Patients will receive oral capecitabine (1000 mg/m\^2 BID on Days 1 to 15 ) plus IV oxaliplatin (130 mg/m\^2 on Day 1) during each 3-week cycle for up to 8 cycles (6 months).
Intervention: Oxaliplatin
Outcomes
Primary Outcomes
Disease-free survival rate
Time Frame: 3 years
Secondary Outcomes
- Overall survival(5 years)
- Incidence of adverse events(5 years)