Efficacy of Pilocarpine As a Secretagogue Versus Artificial Tears for the Treatment of Dry Eye

Not Applicable

Completed

• Conditions: Dry Eye Disease (DED)
• Interventions: Drug: Pilocarpine; Drug: artificial tears

• Registration Number: NCT06752278
• Lead Sponsor: Al-Azhar University

Brief Summary

Management approaches for dry eye disease (DED) typically start with low-risk, easily accessible, patient-applied therapies like artificial tears for early-stage disease. As the condition worsens, treatment progresses to more advanced therapies for severe forms of DED. This study aims to compare the effectiveness and safety of pilocarpine as a secretagogue versus artificial tears in the treatment of dry eye disease. Our goal is to provide reliable, high-quality evidence regarding the efficacy of secretagogues, thereby contributing to the development of recommendations that aid clinicians in their decision-making process

Detailed Description

Not available

Study Timeline

• Study Start: 2024-10-01
• Status Verified: 2024-12
• Primary Completion: 2024-12-01
• Study Completion: 2024-12-20
• Study First Submitted: 2024-12-27
• Study First Submitted QC: 2024-12-27
• Last Update Submitted: 2024-12-27
• Study First Posted: 2024-12-30
• Last Update Posted: 2024-12-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients diagnosed with DED

Exclusion Criteria

• Previous Occular surgery.
• Refuse to particupate.
• Patients with sjogren syndrome

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
pilocarpine group	Pilocarpine	-
artificial tears group	artificial tears	-

Primary Outcome Measures

Name	Time	Method
Ocular Surface Disease Index	At the baseline and after 6 weeks
tear film break-up time	At the baseline and after 6 weeks

Trial Locations

Locations (1)

Al-Azhar university; 🇪🇬 Damietta, Egypt