Impact of Blueberries on Uric Acid and Quality of Life

Not Applicable

Completed

• Conditions: Hyperuricemia
• Interventions: Dietary Supplement: Blueberry Powder; Other: Placebo Powder

• Registration Number: NCT01532622
• Lead Sponsor: University of Mississippi Medical Center

Brief Summary

The purpose of this study is to determine the impact of blueberries on uric acid in patients with hyperuricemia that are not receiving uric acid pharmacotherapy. The central hypothesis the investigators propose is that daily blueberries added to a pre-existing diet will promote uric acid lowering and improve quality of life without detriment to vital signs.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2012-01-30
• Study First Submitted QC: 2012-02-13
• Study First Posted: 2012-02-14
• Status Verified: 2013-10
• Primary Completion: 2013-10
• Study Completion: 2013-10
• Last Update Submitted: 2013-10-18
• Last Update Posted: 2013-10-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• 18 years or older
• Uric acid > 6.0 mg/dL

Exclusion Criteria

• Current moderate-to-severe symptomatic gout
• Currently receiving gout pharmacotherapy
• Current participation in another clinical trial
• Documented non-compliance or consistent missed appointments
• Women who are pregnant or nursing

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Blueberry Powder	Blueberry Powder	Patients will take 30 grams of blueberry powder daily for up to 30 days.
Placebo Powder	Placebo Powder	Patients will take 30 grams of placebo powder daily for up to 30 days.

Primary Outcome Measures

Name	Time	Method
Change from Baseline and Placebo in Uric Acid Level in Patients Randomized to Treatment Group	Baseline, ~30 days later	Percent change in uric acid level from baseline after 30 days of treatment with blueberry powder. Since this is designed as a crossover trial, baseline could represent uric acid level at the beginning of the study or after at least a 2-week washout period following placebo administration.

Secondary Outcome Measures

Name	Time	Method
Body Weight	Baseline, ~30 days, ~45 days, ~75 days	Percent change and absolute change of body weight from baseline and placebo
Blood Pressure	Baseline, ~30 days, ~45 days, ~75 days	Percent change and absolute change of blood pressure from baseline and placebo
Quality of Life	Baseline, ~30 days, ~45 days, ~75 days	Quality of life will be assessed using the Health Assessment Questionnaire-Disability Index (HAQ-DI)

Trial Locations

Locations (1)

University of Mississippi Medical Center; 🇺🇸 Jackson, Mississippi, United States