A randomised controlled trial of vitamin D supplementation vs placebo on cognitive and emotional outcomes

Completed

• Conditions: Cognitive function in healthy volunteers; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12610000318088
• Lead Sponsor: The University of Queensland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-04-20
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 210

Inclusion Criteria

aged 18 years or over
provision of consent to participate.

Exclusion Criteria

1) current use of vitamin D or calcium supplements;
2) having past adverse reactions to vitamin supplements;
3) current or recent use of psychotropic medications or medications which may influence vitamin D absorption (e.g. cholestyramine, orlistat)
4) current or past diagnosis of psychotic disorders;
5) serious neurologic illnesses including stroke, brain tumours, head trauma, multiple sclerosis, epilepsy, movement disorders or migraine in treatment;
6) drug dependency on alcohol or illicit substances;
6) intellectual disability
7) pregnancy or current breast feeding, or potential to become pregnant during the trial;
8) history of severe renal impairment,
9) recent or current use of immunosuppressive therapy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Response inhibition - stop signal task[Measured at baseline and 6 weeks];Spatial working memory - N-back task[Measured at baseline and 6 weeks];Cognitive flexibility - set shifting task[Measured at baseline and 6 weeks]

Secondary Outcome Measures

Name	Time	Method
Peters Delusional Inventory[Measured at baseline and 6 weeks];Speech perception - White noise task[Measured at baseline and 6 weeks];Aggression and hostility - Aggression Questionaire[Measured at baseline and 6 weeks];Anger - State Trait Anger Expression Inventory[Measured at baseline and 6 weeks];Anxiety symptoms - State Trait Anxiety Inventory[Measured at baseline and 6 weeks];Depressive symptoms - Beck Depression Questionnaire[Measured at baseline and 6 weeks];Sustained attention - Sustained Attention to Response Test[Measured at baseline and 6 weeks]