Vitamin D and Liver Health in North India

Not Applicable

• Registration Number: CTRI/2023/11/060045
• Lead Sponsor: Indian Council of Medical Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 19 December 2023

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Age 18-60 years

Body Mass Index ( >25 Kg/m2)

NAFLD by ultrasound

Baseline level of 25 hydroxy vitamin D <30ng/dl.

Exclusion Criteria

a)Known case of diabetes mellitus.

b)Known case of HIV infection.

c)On any medication within last one month which could potentially influence insulin secretion, insulin sensitivity, vitamin D or calcium metabolism (eg metformin, thiazolidione, steroids etc) and on any medication that activate steroid and xenobiotic receptor and drugs used in transplantation (e.g. steriods, calcitonin etc.)

d)Severe end organ damage or chronic diseases: renal/ hepatic failure, any malignancy, nephrotic syndrome, malabsorption etc.

e)Primary or tertiary hyperparathyroidism, granulomatous disorders (e.g. sarcoidosis) and any lymphomas

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Vitamin D supplementation could Increase/preserve leucocyte telomerase length and activity, thus having positive effects on ageing. <br/ ><br>Timepoint: Vitamin D supplementation could Increase/preserve leucocyte telomerase length and activity, thus having positive effects on ageing will be assessed at enrolment time and after 6 month intervention. <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
Vitamin D supplementation could decreased lipids, metabolic parameters, anthropometry and body fat measurements.Timepoint: Glycemic and lipid profile, metabolic parameters, body composition [Dual-energy X-ray absorptiometry (DXA)] will be assessed at enrolment time and after 6 month intervention.;Vitamin D supplementation could Improve insulin action and glucose physiology, leading to lowering of blood glucose levels in persons with prediabetes.Timepoint: Blood glucose and insulin levels will be be assessed at enrolment time and after 6 month intervention.