Vitamin D for people at risk of dementia

Not Applicable

Completed

• Conditions: Age-associated cognitive decline, subjective memory concerns and/or family history of dementia; Mental and Behavioural Disorders

• Registration Number: ISRCTN79265514
• Lead Sponsor: niversity of Exeter

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-07-23
• Study Completion: 2023-07-31
• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 685

Inclusion Criteria

Current inclusion criteria as of 23/04/2020:

1. Age 50 and over
2. Already registered as a participant on the PROTECT study
3. Fulfilling research criteria for dementia risk: Either (1) Performing at least one Standard Deviation below age-matched population norms in two cognitive tests as measured using the validated PROTECT and online cognitive test battery; and/or (2) Reporting subjective memory concerns; and/or (3) Reported family history of dementia
4. Fulfilling criteria for vitamin D deficiency risk: Defined by a self-reported scale to be completed on registration.
5. Access to a computer and the internet.

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Previous inclusion criteria:

1. Aged 50 years and over
2. Already registered as a participant on the PROTECT study
3. Fulfilling the AACD criteria: performing at least standard deviation below age-matched population norms in two cognitive tests, as measured using the validated PROTECT and CogTrackTM online cognitive test batteries
4. Fulfilling criteria for vitamin D deficiency risk (defined by a self-reported scale to be completed upon registration (based on Annweiler et al., 2017)
5. Access to a computer and the internet

Exclusion Criteria

1. Diagnosed with dementia
2. Already participating in another active interventional clinical trial
3. Regularly taking any supplement containing vitamin D:
3.1. If the supplement is prescribed for a pre-existing condition, the participant will be excluded
3.2. If the supplement is bought over the counter, the participant will have the option of stopping the supplement and re-registering for the trial after a 28 day washout period
4. Prescribed the medication Digoxin (Lanoxin)

Study & Design

• Study Type: Interventional
• Study Design: Not specified