Multisystem phenotyping of severe ACUte asthma at the Paediatric Intensive Care Unit

Recruiting

• Conditions: Asthma; 10006436

• Registration Number: NL-OMON54638
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

- Between 2-18 years of age
- Referred to a PICU with severe acute asthma for which intravenous salbutamol
is started (according to the criteria of the Dutch protocol for status
asthmaticus, clinical judgement of the attending physician and asthma scores).
-Written informed consent obtained from the parents/ local guardians/ patient
when 12 years of older.
-Patients included in the SysPharmPediA study (NL 55788.041.15) with unstable
asthma GINA step 3.

Exclusion Criteria

- Cystic Fibrosis
- Previous inclusion in the study

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Severe acute asthma phenotypes at the PICU based on differences in bacterial<br /><br>metabolomics and microbiomics, viromics, breathomics, transcriptomics and<br /><br>cytokine biomarkers. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>None applicable.</p><br>