Phenotypes of Adults with Non-Atopic Asthma.
Recruiting
- Conditions
- on-atopic asthmaAdultsNiet-atopisch astmaVolwassenen
- Registration Number
- NL-OMON29228
- Lead Sponsor
- Medical Centre Leeuwarden, Department of respiratory medicine
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
1. Outpatients with non-atopic asthma, determined by negative alatop;
2. Age 18 yrs or older;
Exclusion Criteria
1. Patients with smoking history of > 10 packyears and persistent airflow obstruction (post bronchodilator FEV1 < 80%pred): excluded if reversibility in FEV1 < 12% predicted OR TLCO< 80%pred;
2. Pregnancy;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Study 1: Characterizing patients with non-atopic asthma with respect to clinical, functional and inflammatory parameters. Separate subtypes of non-atopic asthma will be defined by unbiased cluster analysis.<br><br /><br /><br>Study 2: The association between level of NO in exhaled air, percentage of eosinophils in induced sputum and extent of sinus disease as assessed by CT sinus score will be investigated by correlation analyses.<br><br /><br /><br>Study 3: Sensitivity, specificity, positive and negative predictive value of the eNose in detecting sinus disease in non-atopic asthma. <br>
- Secondary Outcome Measures
Name Time Method