Adult Onset asthma and Inflammatory Sub-phenotypes

Conditions: adult onset asthma
asthma
10006436

Registration Number: NL-OMON33012

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 200

Inclusion Criteria

- 18 to 75 years
- Adult-onset asthma (i.e. asthma that started after the age of 18)
- Physicians diagnosis of asthma < 1 year prior enrolment
- Documented reversibility in FEV1 of > 12 % predicted and 200 ml or airway hyperresponsiveness to inhaled methacholine (PC20 < 8 mg/ml)

Exclusion Criteria

- Patients with smoking history > 10 packyears, fixed airflow obstruction (post bronchodilator FEV1 < 80%) and reversibility in FEV1 < 12% predicted.
- Pregnancy
- Other pulmonary diseases or non-related major-comobidities.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>This is a descriptive study, without real outcome parameters. By performing<br /><br>cluster analysis, several phenotypes of recent late onset asthma will be<br /><br>defined.<br /><br><br /><br>Potential risk factors are assessed at baseline (phase 1) and related to the<br /><br>change in lungfunction over time and exacerbation rate. Linear regression will<br /><br>be used to analyse the association between potential predicting factors and<br /><br>decline in FEV1 (ml.yr) and exacerbation rate during the follow-up. Logistic<br /><br>regression will be used to estimate RR/OR with 95% CI*s for accelerated decline<br /><br>in FEV1 and exacerbation rate. </p><br>

Secondary Outcome Measures