Astma ontstaan op volwassen leeftijd: de eerste twee jaar.

Recruiting

Conditions: adult onset asthmaphenotypingmarkers

Registration Number: NL-OMON28266

Lead Sponsor: Academic Medical centre

Brief Summary: /A

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 200

Inclusion Criteria

1. 18 to 75 years;

2. Adult-onset asthma (i.e. asthma that started after the age of 18);

Exclusion Criteria

1. Patients with smoking history > 10 packyears, who have fixed airflow obstruction (post bronchodilator FEV1 < 80% and FEV1/FVC < 0.70) and without reversibility in FEV1 > 12 % predicted and 200 ml;

2. Pregnancy;

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Phase 1: Cross-sectional assessment.<br /><br>3-4 separate subtypes will be defined by cluster analysis; risk factors of severe disease and poor quality of life will be defined.<br><br /><br /><br>Phase 2: Follow-up during 4 years.<br /><br>The cohort of patients will be prospectively followed for 4 years. The course of the disease during treatment by their own physician/ pulmonologist will be observed. Potential risk factors will be assessed at baseline (patients’ clinical characteristics, different non-invasive markers of airway inflammation, lungfunction, airway hyperresponsiveness) and related to the change in lung function and exacerbation rate over time.<br><br>

Secondary Outcome Measures