Prone Positioning vs. Prone Positioning and NO Inhalation in COVID-19 ARDS.

Recruiting

• Conditions: Respiratory Distress Syndrome
• Interventions: Drug: Nitric oxide; Behavioral: prone positioning

• Registration Number: NCT05715788
• Lead Sponsor: Shanghai Zhongshan Hospital

Brief Summary

The investigators aim to investigate the effects of prone positioning and prone positioning with NO inhalation for COVID-19 patients with ARDS.

Detailed Description

The investigators aim to investigate the effects of prone positioning and prone positioning with NO inhalation for COVID-19 patients with ARDS. Patients with COVID-19-associated ARDS were ventilated in prone position with or without NO inhalation, the arterial blood gas (ABG) tests were performed at 16 hours after prone positioning.

Study Timeline

• Study Start: 2022-12-21
• Status Verified: 2023-02
• Study First Submitted: 2023-02-04
• Study First Submitted QC: 2023-02-04
• Last Update Submitted: 2023-02-04
• Study First Posted: 2023-02-08
• Last Update Posted: 2023-02-08
• Primary Completion: 2023-12
• Study Completion: 2023-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Adult patients with COVID-19 associated ARDS

Exclusion Criteria

• patients who have contraindication for prone positioning, including pregnant, post-abdomen surgery within a week; hypercapnic respiratory failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients ventilated in prone position with NO inhalation	prone positioning	Patients ventilated in prone position with NO inhalation
patients ventilated in prone position	prone positioning	Patients ventilated in prone position
Patients ventilated in prone position with NO inhalation	Nitric oxide	Patients ventilated in prone position with NO inhalation

Primary Outcome Measures

Name	Time	Method
P/F ratio	16 hours	P/F ratios in each group

Trial Locations

Locations (1)

Zhongshan Hospital, Fudan University; 🇨🇳 Shanghai, Shanghai, China