Determine the Effects of Prone Positioning and Nitric Oxide in Adult COVID-19 Patients With ARDS by Electrical Impedance Tomography
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- oxygenation status
研究概览
简要总结
We aims to investigate the effects of prone positioning and nitric oxide inhalation in adult patients who is diagnosed with COVID-19 associated acute respiratory distress syndrome by electrical impedance tomography.
详细描述
The investigators aim to investigate the effects of prone positioning and nitric oxide inhalation in adult patients who is diagnosed with COVID-19 associated acute respiratory distress syndrome by electrical impedance tomography (EIT).
The EIT assessment is performed in patients ventilated in supine position, supine position with NO inhalation for 1 hour, prone position for 1 hour, prone position for 2 hours with NO inhalation for 1 hour, prone position for 3 hours, prone position for 16 hours, re-supine position for 3 hours. Arterial blood gas (ABG) analysis results, ventilator parameters and hemodynamic parameters are also recorded at each time point.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients who have COVID-19-associated acute respiratory distress syndrome
排除标准
- •patients who refuse to participate in the study; unable to use EIT, such as open-chest surgery with chest tube placement; have contraindication for prone positioning, including pregnant, post-abdomen surgery within a week; hypercapnic respiratory failure.
研究组 & 干预措施
Ventilation in supine position and NO inhalation
Patients are ventilated in supine position with NO inhalation for 1 hour.
干预措施: NO inhalation (Drug)
Ventilation in prone position for 1 hour
Patients are ventilated in prone position for 1 hour.
干预措施: prone postion (Behavioral)
Ventilation in prone position for 2 hours plus NO inhalation for 1 hour
Patients are ventilated in prone position for 1 hour followed by ventilation in prone position with NO inhalation for 1 hour.
干预措施: prone postion (Behavioral)
Ventilation in prone position for 2 hours plus NO inhalation for 1 hour
Patients are ventilated in prone position for 1 hour followed by ventilation in prone position with NO inhalation for 1 hour.
干预措施: NO inhalation (Drug)
Ventilation in prone position for 3 hours
Patients are ventilated in prone position for 1 hour followed by ventilation in prone position with NO inhalation for 1 hour. Then they are ventilated in prone position alone for 1 hour.
干预措施: prone postion (Behavioral)
Ventilation in prone position for 16 hours
Patients are ventilated in prone position for 1 hour followed by ventilation in prone position with NO inhalation for 1 hour. Then they are ventilated in prone position alone for 14 hours.
干预措施: prone postion (Behavioral)
结局指标
主要结局
oxygenation status
时间窗: 1 day
To evaluate the oxygenation parameters
regional distribution of pulmonary perfusion
时间窗: 1 day
To evaluate the effect of prone positon and NO inhalation on pulmonary blood flow distribution.
regional distribution of pulmonary ventilation
时间窗: 1 day
To evaluate the effect of prone positon and NO inhalation on pulmonary vetilation distribution.
次要结局
未报告次要终点