Studying the Impact of Thermal Stress (Heat) Representative of Occupational Settings on Pulmonary Absorption and Toxicokinetics of 3 Organic Solvents
试验速览
- 阶段
- 不适用
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- Cardiac frequency
研究概览
简要总结
In Quebec, thousands of workers are concomitantly exposed to heat and chemical compounds. Exposure to heat induces physiological responses that help maintaining a stable body temperature. Those changes can affect organ functions implicated in absorption and metabolism. According to literature, those changes could lead to increased concentrations of chemical compounds in the body and their toxicity. Therefore, the aim of this study is to evaluate the pulmonary absorption and toxicokinetics of 3 organic solvents in heat stress conditions in volunteers exposed in a inhalation chamber. Results will then be used to develop PBPK models that will allow to predict organic solvent kinetics when coexposed with heat.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Body mass index between 18,5 et 25 kg/m3
排除标准
- •Respiratory, cardiovascular and neurological problems
- •History of exposure to solvents
- •Chronic medication
- •Abusive and/or chronic alcohol consumption
- •Alcohol consumption 24h before or 18h following exposure
研究组 & 干预措施
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat stress (21) (Other)
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat stress (25) (Other)
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat stress (30) (Other)
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat Stress (21) +TOL (Other)
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat stress (25) + TOL (Other)
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat stress (21) + TOL (Other)
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat stress (21) + ACE (Other)
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat stress (25) + ACE (Other)
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat stress (21) + TOL (dermal) (Other)
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat stress (25) + TOL (dermal) (Other)
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat stress (30) + TOL (dermal) (Other)
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat stress (30) + ACE (Other)
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat stress (21) + DCM (Other)
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat stress (25) + DCM (Other)
Heat stress
4h exposure to heat stress alone or in combination with different solvents. Solvent concentrations are equal to their TLV. Heat conditions are 21, 25 and 30°C (WBGT). Inhalation exposure for all solvents and demal exposure for toluene.
干预措施: Heat stress (30) + DCM (Other)
结局指标
主要结局
Cardiac frequency
时间窗: 4hour
Cardiac frequency will be monitored continuously for 4hour with a respirometer
Minute ventilation
时间窗: 4hour
Minute ventilation will be monitored continuously for 4hour with a respirometer
Tidal volume
时间窗: 4hour
Tidal volume will be monitored continuously for 4hour with a respirometer
Solvent in blood
时间窗: 4,5hour
Solvents concentrations will be measured in blood samples collected at different times (t=0, 2, 4 and 4.5hour).
Solvent or metabolite in urine
时间窗: 18hour
Solvent or metabolite concentrations (o-cresol for toluene exposures) will be measured for urine samples collected at different times (t=0, 4, 10 and 18hour).
Solvent in exhaled air
时间窗: 6hour
Solvents concentrations will be measured in exhaled air samples collected at different times (t=0, 1.5, 3, 4.5 and 6hour).
Respiratory rate
时间窗: 4hour
Respiratory rate will be monitored continuously for 4hour with a respirometer
次要结局
- Oxygen consumption(4hour)
- Carbonic dioxide production(4hour)
- Body temperature(4hour)
研究者
Sami Haddad
Professor
Université de Montréal