Investigating the genetic building blocks of emotion, cognition and behaviour in the general population: imaging*

Withdrawn

Conditions: hippocampus volume in non-affected persons
memory
10012272

Registration Number: NL-OMON37612

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 125

Inclusion Criteria

- Participants from the Utrecht Health Project and Building Blocks study
- Available APOE genotype: either
- Aged 18-50
- Signed Informed consent of aforementioned studies to be contacted for subsequent studies

Exclusion Criteria

- MR contraindications (see also 5.1.2): Pregnancy, non-removable, ferrous objects in or around the body (e.g. braces, glasses, pacemaker, metal fragments, tattoos)
- Major medical condition
- Claustrophobia
- History of somatic diseases potentially affecting brain function and/or structure
- Current or past psychiatric disorders (with the exception of past major depressive disorder)
- Medication potentially affecting brain function (such as antipsychotics or anti-epileptics)

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Functional activation patterns in the hippocampus (3T) and hippocampal<br /><br>substructure volumes and total volume (7T).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>We will measure parameters which might intervene with the main study parameter<br /><br>(confounders: age, gender, years of education).<br /><br>Assessments already available include: 1) from the Building blocks study:<br /><br>standardised diagnostic psychiatric interview, symptom rating, medical history,<br /><br>neuropsychological and memory function; 2) from the UHP: wide range of general<br /><br>health data, including cholesterol, HDL, BMI, health care consumption as well<br /><br>as linkage with the computerized medical files of the general practitioners.</p><br>