Assessment of Eyelid Topology and Kinetics Based on Deep Learning Method

Recruiting

• Conditions: Eyelid Diseases
• Interventions: Other: Photography

• Registration Number: NCT04921020
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

This study plans to assess eyelid topology (such as margin reflex distance, eyelid contour, and corneal exposure area) and blinking (such as frequency, velocity, and duration), using deep learning method to automatically extract eyelid topological features, and to predict subtypes of levator function, using deep learning method to extract blinking features, in order to provide new ideas and means to assess eyelid topology and kinetics.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-08-01
• Status Verified: 2021-06
• Study First Submitted: 2021-06-01
• Study First Submitted QC: 2021-06-08
• Last Update Submitted: 2021-06-08
• Study First Posted: 2021-06-10
• Last Update Posted: 2021-06-10
• Primary Completion: 2025-08-01
• Study Completion: 2026-08-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

1. normal volunteers without eyelid diseases
2. patients with blepharoptosis
3. patients with blepharospasm
4. patients with dry eye disease
5. patients with Graves' disease

Exclusion Criteria

variable ptosis (e.g., myasthenia gravis), entropion, ectropion, enophthalmos, exophthalmos, strabismus, and abnormalities of pupil

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with Graves' disease	Photography	-
Patients with blepharospasm	Photography	-
Normal participants	Photography	-
Patients with dry eye disease	Photography	-
Patients with blepharoptosis	Photography	-

Primary Outcome Measures

Name	Time	Method
subtypes of levator function	through study completion, 5 years	Levator function is classified into three categories: good, fair and poor
one-dimensional parameters of eyelid topology	through study completion, 5 years	Palpebral fissure length \[Margin reflex distance 1, Margin reflex distance 2\], Lid length \[Upper lid length, Lower lid length\], Multiple mid-pupil lid distances
two-dimensional parameters of eyelid topology	through study completion, 5 years	Palpebral fissure area \[Medial area, Corneal area, Lateral area\]

Trial Locations

Locations (1)

Juan Ye; 🇨🇳 Hangzhou, Zhejiang, China