The Influence of Physical Activity on the Effect of Cognitive Behavioural Therapy, Neurobiological Parameters and Information Processing in Patients With Panic Disorder With/Without Agoraphobia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Panic Disorder
- Sponsor
- Charite University, Berlin, Germany
- Enrollment
- 46
- Primary Endpoint
- Hamilton Rating Scale for Anxiety (CIPS 1995)
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
Physical activity (treadmill) supports the effect of cognitive behavioural therapy in patients with panic disorder with/without agoraphobia
Detailed Description
Patients undergo cognitive behavioural therapy consisting of 8 group sessions within 1 month. All patients additionally complete a training of physical activity, which starts simultaneously to therapy and runs for 8 weeks (3 times/week, 30 minutes each). Half of the patients complete training on a treadmill while the other half completes a training programme of low intensity physical activity without cardiovascular activation. Flanking EEG (electroencephalogram) recordings shall help clarify biological processes underlying the therapeutical process.
Investigators
Prof. Dr. Andreas Ströhle
Prof. Dr.
Charite University, Berlin, Germany
Eligibility Criteria
Inclusion Criteria
- •Subject familiarized with experimental procedure and had given written informed consent
- •Diagnosis of panic disorder with or without agoraphobia according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
- •Sufficiently able to communicate with investigator, answer questions and fill in questionnaires
- •Reachability of patient for treatment and follow-up
Exclusion Criteria
- •Other psychiatric illnesses like schizophrenia, substance abuse or severe depressive episode
- •Acute suicidal tendency
- •Epilepsy or other illness of the central nervous system (e.g. brain tumor, encephalitis)
- •Existence of contraindication against physical exercise
- •Pregnancy or breastfeeding
- •Changes of psychopharmacological treatment within the last 4 weeks
Outcomes
Primary Outcomes
Hamilton Rating Scale for Anxiety (CIPS 1995)
Time Frame: up to 28 weeks (follow up)
Global interviewer rated measure for anxiety and severity indicator of an anxiety disorder
Secondary Outcomes
- Panic and Agoraphobia Scale (Bandelow et al. 1995)(Baseline, 4 weeks, 8 weeks and 28 weeks (follow up))
- Beck Anxiety Inventory (CIPS 1995)(Baseline, 4 weeks, 8 weeks and 28 weeks (follow up))
- Clinical Global Index (CIPS 1995)(Baseline, 4 weeks, 8 weeks and 28 weeks (follow up))
- Beck Depression Inventory (CIPS 1995)(Baseline, 4 weeks, 8 weeks and 28 weeks (follow up))