Impact of Combined Behavioral Interventions on Cognitive Outcomes in MCI
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Mild Cognitive Impairment
- Sponsor
- University of California, San Diego
- Enrollment
- 52
- Locations
- 1
- Primary Endpoint
- Rivermead Behavioral Memory Test
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Vast evidence supports use of physical exercise and cognitive stimulation for lowering risk for cognitive decline and dementia, with combinations of non-pharmacological interventions providing greatest promise for impacting cognitive aging. This, paired with limited cognitive benefits from pharmacological interventions in dementia, has shifted focus to non-pharmacological interventions administered earlier in the disease course. This application, therefore, proposes a randomized controlled trial (RCT; 12-week active intervention, 3- and 6-month follow-up) comparing 3 conditions: walking program (guided progressive increases in weekly step counts), computer-based cognitive training program (Brain HQ, Posit Science), and combination of the exercise and cognitive program, on cognitive, functional, and diagnostic outcomes in 60 sedentary, community-dwelling adults with mild cognitive impairment (MCI).
Investigators
Amy Jak
Associate Professor of Psychiatry
University of California, San Diego
Eligibility Criteria
Inclusion Criteria
- •MCI diagnosis (can be self referral, will determine eligibility at baseline)
Exclusion Criteria
- •Dementia diagnosis
- •Head trauma
- •Neuro/psychiatric disorders
- •Current substance dependence
- •Sensory/mobility deficits
- •No more than 1 hour of purposeful, aerobic activity/week
- •Currently engaging in any other brain-stimulating computer program (No more than 1 hour a week)
Outcomes
Primary Outcomes
Rivermead Behavioral Memory Test
Time Frame: 12 weeks
The Rivermead Behavioral Memory Test (RBMT) is an ecologically valid assessment of cognitive functioning that tests some skills specifically trained in the CT condition (e.g., name learning, and story learning) but also additional untrained skills such as prospective memory. Belongings subtest scaled scores: Minimum score = 1, Maximum score = 19; higher values represent better performance.
Everyday Cognition Scale
Time Frame: 12 weeks
The Everyday Cognition Scale (ECog) assesses (via informant report) everyday cognitive functioning in memory, language, visuospatial, and executive functioning domains. Average total score was used: Minimum = 1, Maximum = 4, higher scores indicate greater impairment
Older Peoples Quality of Life Questionnaire
Time Frame: 12 weeks
Self report assessment of quality of life specific to older adults. Assessment covers life overall, health, social relationships and participation, independence, control over life and freedom, home and neighborhood, psychological and emotional well-being, financial circumstances, leisure/activities, and culture and religion. Total score minimum = 35, max = 175; lower scores indicate better quality of life.