Angiopoietin Dysregulation to Predict Adverse Outcomes in Cardiac Surgery: the Prospective
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- correlation between occurence of abnormal angiopoietin 2 concentration (ng/ml) and occurence of major cardiovascular event
研究概览
简要总结
Cardiac surgery and cardiopulmonary bypass can lead to systemic organ failure trough excess inflammation and endothelial injury. The angiopoietin family represented by angiopoietin 1 and 2 can reflect endothelial injury by a decrease in angiopoietin 1 and an increase in angiopoietin 2. The investigators hypothesized that angiopoietin dysregulation could reflect organ failure related to cardiac surgery.
The purpose of this project is to assess the association between angiopoietin dysregulation and adverse outcomes on cardiac surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patient scheduled for cardiac surgery under cardiopulmonary bypass
排除标准
- •patient less than 18 years old,
- •redo surgery,
- •urgent surgery,
- •endocarditis,
- •aortic root repair surgery
- •aortic dissection
- •heart beating surgery,
- •heart transplantation
结局指标
主要结局
correlation between occurence of abnormal angiopoietin 2 concentration (ng/ml) and occurence of major cardiovascular event
时间窗: 28 days
major cardiovascular event are myocardial infraction, stroke, acute kidney injury, cardiovascular death
Correlation between abnormal angiopoietin 1 concentration (ng/ml) and number of major cardiovascular event
时间窗: 28 days
major cardiovascular event are myocardial infraction, stroke, acute kidney injury, cardiovascular death
次要结局
- Correlation between abnormal angiopoietin 2 concentration (ng/ml) and number of postoperative pulmonary complications(28 days)
- Correlation between abnormal angiopoietin 2 concentration (ng/ml) and mortality at 3 months(3 months)
- Correlation between abnormal angiopoietin 1 concentration (ng/ml) and mortality at 6 months(6 months)
- Correlation between abnormal angiopoietin 1 concentration (ng/ml) and mortality at 3 months(3 months)
- Correlation between abnormal angiopoietin 2 concentration (ng/ml) and mortality rate at 12 months(12 months)
- Correlation between occurence of abnormal angiopoietin 2 concentration (ng/ml) and mortality at 6 months(6 months)
- Correlation between abnormal angiopoietin 1 concentration (ng/ml) and number of postoperative pulmonary complications(28 days)
- Correlation between abnormal angiopoietin 1 concentration (ng/ml) and mortality rate at 12 months(12 months)