Dutch Belgian randomised lung cancer screening trial (NELSON)

Not Applicable

Completed

• Conditions: ung cancer; Cancer; Lung cancer

• Registration Number: ISRCTN63545820
• Lead Sponsor: Erasmus Medical Centre (Netherlands)

Brief Summary

1. 2007 results in: http://www.ncbi.nlm.nih.gov/pubmed/17709835 2. 2009 patient participation results in: http://www.ncbi.nlm.nih.gov/pubmed/19282345 3. 2009 results on management of lung nodules in: http://www.ncbi.nlm.nih.gov/pubmed/19955524 4. 2010 2-year follow up data in: http://www.ncbi.nlm.nih.gov/pubmed/20627916 5. 2011 results on health-related quality of life in: http://www.ncbi.nlm.nih.gov/pubmed/21148229 6. 2012 generalisability of results in: http://www.ncbi.nlm.nih.gov/pubmed/22459203 7. 2012 complications results in: http://www.ncbi.nlm.nih.gov/pubmed/22491665 8. 2012 results in: http://www.ncbi.nlm.nih.gov/pubmed/22302298 9. 2012 results in: http://www.ncbi.nlm.nih.gov/pubmed/22323577 10. 2013 follow-up results in: http://www.ncbi.nlm.nih.gov/pubmed/23688060 11. 2013 results in: http://www.ncbi.nlm.nih.gov/pubmed/23845716 12. 2014 results in: http://www.ncbi.nlm.nih.gov/pubmed/25282285 13. 2014 results in: http://www.ncbi.nlm.nih.gov/pubmed/25282284 14. 2015 results in: http://www.ncbi.nlm.nih.gov/pubmed/25182625 15. 2015 results in: http://www.ncbi.nlm.nih.gov/pubmed/25287262 16. 2015 results in: http://www.ncbi.nlm.nih.gov/pubmed/25413965 17. 2015 results in: http://www.ncbi.nlm.nih.gov/pubmed/25664626 18. 2015 results in: http://www.ncbi.nlm.nih.gov/pubmed/25962863 19. 2016 results in: http://www.ncbi.nlm.nih.gov/pubmed/27283862 20. 2016 results in: http://www.ncbi.nlm.nih.gov/pubmed/27364640 21. 2016 results in: https://www.ncbi.nlm.nih.gov/pubmed/27420360 22. 2018 results in:https://www.ncbi.nlm.nih.gov/pubmed/29661918 23. 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/29056601 24. 2019 results in: https://www.ncbi.nlm.nih.gov/pubmed/30591535 (added 16/05/2019) 25. 2018 results in https://www.ncbi.nlm.nih.gov/pubmed/29775805 (added 25/09/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-06-07
• Study Completion: 2015-12-31
• Last Update Posted: 29 October 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 15600

Inclusion Criteria

1. Born between 1928 and 1956
2. Smoked:
2.1. More than 15 cigarettes per day for more than 25 years, or
2.2. More than 10 cigarettes per day for more than 30 years
3. Current or former smokers who quit smoking less than or equal to 10 years ago

Exclusion Criteria

1. Moderate or bad self-reported health who were unable to climb two flights of stairs
2. Body weight greater than or equal to 140 kg
3. Current or past renal cancer, melanoma or breast cancer
4. Lung cancer, diagnosed less than five years ago or greater than or equal to five years but still under treatment
5. Had a chest CT examination less than one year before they filled in the first NELSON questionnaire

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ung cancer mortality (reduction)

Secondary Outcome Measures

Name	Time	Method
<br> 1. Cost-effectiveness<br> 2. Quality of life<br>