Ultrasound Evaluation of Abdominal Muscle Thickness During Mechanical Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Thickness of the abdominal muscles (mm)
研究概览
简要总结
Weakness of respiratory muscles is frequent after several days of mechanical ventilation. Thereby an acquired diaphragm weakness has been demonstrated, linked to an atrophy which may be identified by a decrease of muscle thickness in echography. This study aims to evaluate with ultrasound the variation of thickness of abdominal muscles after 7 days of mechanical ventilation.
详细描述
Weakness of respiratory muscles is frequent after several days of mechanical ventilation. Thereby an acquired diaphragm weakness has been demonstrated, linked to an atrophy which may be identified by a decrease of muscle thickness in echography. Weakness of expiratory muscles is also frequent after 7 days of mechanical ventilation, however his cause is not clear: is it present at admission notably in elderly patients, or acquired on mechanical ventilation ? Ultrasound allows to measure the thickness of abdominal muscles which correlates with their strength. This study aims to evaluate with ultrasound the variation of thickness of abdominal muscles after 7 days of mechanical ventilation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient affiliated or entitled to a social security plan
- •Expected duration of mechanical ventilation > 7 days
- •Trusted person/relative who has signed a consent to participate in the study
排除标准
- •Patient with a pre-existing neuromuscular pathology
- •No access to ultrasound Windows (dressing, drainages...)
- •Patient transferred from another intensive care unit
- •Patient Under guardianship or curators
结局指标
主要结局
Thickness of the abdominal muscles (mm)
时间窗: Day 7
It is the sum of the thickness of rectus abdominal muscle + external oblique + internal oblique + transverse muscles.
次要结局
- Duration of curarization (Day)(At intensive care unit discharge)
- Thickness of the rectus abdominal muscle (mm)(Immediately after the successful extubation of the patient)
- Thickness of the rectus abdominal muscles (mm)(Day 7)
- Diaphragmatic thickness (mm)(Immediately after the successful extubation of the patient)
- Thickness of the transverse abdominal muscle (mm)(Immediately after the successful extubation of the patient)
- Thickness of the external oblique abdominal muscles (mm)(Day 7)
- Number of day with a contraction of the transverse abdominal muscle(From day 1 to day 7)
- Thickness of the external oblique abdominal muscle (mm)(Immediately after the successful extubation of the patient)
- Thickness of the internal oblique abdominal muscle (mm)(Immediately after the successful extubation of the patient)
- Number of day between day 7 and successful extubation day (days)(From Day 7 to the day when the patient will be extubated successfully)
- Thickness of the transverse abdominal muscles (mm)(Day 7)
- Maximum expiratory pressure (l/min)(Day 7)
- Thickness of the internal oblique abdominal muscles (mm)(Day 7)
- Caught peak expiratory flow (CPEF) (cmH2O)(Day 7)
- Duration of sedation (Day)(At intensive care unit discharge)